BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers
نویسندگان
چکیده
منابع مشابه
BRCA 1/2-Mutation Related and Sporadic Breast and Ovarian Cancers: More Alike than Different
No longer is histology solely predictive of cancer treatment and outcome. There is an increasing influence of tumor genomic characteristics on therapeutic options. Both breast and ovarian cancers are at higher risk of development in patients with BRCA 1/2-germline mutations. Recent data from The Cancer Genome Atlas and others have shown a number of genomic similarities between triple negative b...
متن کاملBeyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors
Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown clinical activity in patients with germline BRCA1/2 mutation (gBRCAm)-associated breast and ovarian cancers. Accumulating evidence suggests that PARPi may have a wider application in the treatment of cancers defective in DNA damage repair pathways, such as prostate, lung, endometrial, and pancreatic cancers. Several PARPi are currently i...
متن کاملMRI characteristics of BRCA-associated breast cancers.
1596 Background: Magnetic resonance imaging (MRI) is the preferred imaging modality for screening and diagnosis of breast cancer in BRCA-1and BRCA-2 mutation carriers. However, there is limited data on the radiographic features of BRCA1/2-positive breast cancers on MRI. This study evaluates the MRI characteristics of BRCA1/2 -related breast cancers. METHODS All female BRCA mutation carriers w...
متن کاملPrevalence of BRCA-1 associated protein 1 germline mutation in sporadic malignant pleural mesothelioma cases.
OBJECTIVE 23% of mesothelioma tumor specimens have a mutation in the BRCA1-associated protein 1 (BAP1) gene and germline BAP1 mutations predispose to malignant pleural mesothelioma (MPM). Our aim was to investigate germline BAP1 mutations in sporadic MPM patients. MATERIALS AND METHODS Exonic DNA from peripheral blood leucocytes of 78 MPM patients was screened for germline BAP1 mutation. RE...
متن کاملBRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing.
BRCA mutated ovarian cancers respond better to platinum-based therapy and to the recently approved PARP-inhibitors. There is the need for efficient and timely methods to detect both somatic and germline mutations using formalin-fixed paraffin-embedded (FFPE) tissues and commercially available technology. We used a commercial kit exploring all exons and 50bp exon-intron junctions of BRCA1 and BR...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2017
ISSN: 1465-542X
DOI: 10.1186/s13058-017-0856-z